Stanford University researchers have developed a novel imaging system, Interferometric Image Scanning Microscopy (iISM), that achieves approximately 120 nanometer resolution for living cells without the need for chemical labels. The findings were detailed in Light: Science & Applications in February 2026. This breakthrough allows scientists to observe the intricate structures and movements within cells for extended periods without damaging them.

The iISM system represents a significant step forward in biological imaging. It provides an unprecedented view into cellular processes, which could lead to new discoveries in understanding diseases, developing drugs, and exploring the complex relationships between organisms.

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A key advantage of iISM is its "label-free" approach, meaning it does not require fluorescent tags or dyes that can interfere with cell function or be toxic. The system uses substantially less illumination power, reducing the risk of photodamage and allowing for longer observation times of cellular structures. The research was conducted by Nobel laureate W.E. Moerner, a professor of chemistry and applied physics at Stanford University, and postdoctoral scholar Michelle Küppers. The system is also designed to be compatible with existing commercial confocal platforms.

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